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Final Agenda Now Available - Jason Bielas of FHCRC to Keynote 2014 Event!
작성일 20/06/24 (16:06)조회수 315

View Final Agenda |Sponsor & Exhibit | Present a Poster | Register by July 18 & SAVE up to $400!

ABOUT THE CONFERENCE

The Third Annual Digital PCR event will bring together industry visionaries and early adopters to discuss digital PCR's capabilities, limitations, and future applications. Researchers will examine applications in cancer biomarker and rare mutation detection, non-invasive fetal DNA analysis, and infectious disease quantification, particularly in HIV. Novel digital PCR devices from startups and academic labs will be showcased. Other topics to be addressed include digital PCR integration with existing technologies, solutions for processing difficult samples as well as increasing sample throughput, and guidelines and best practices for digital detection.

Day 1

KEYNOTE PRESENTATION
Advancing Diagnostics with Digital Detection: From Quantifying Ultra-Rare Mitochondrial DNA Mutations to Profiling Tumor-Infiltrating Lymphocytes
Jason H. Bielas, Ph.D., Associate Member, Translational Research Program, Fred Hutchinson Cancer Research Center (FHCRC); Affiliate Assistant Professorship, Department of Pathology, University of Washington

In addition to precise quantification of nucleic acids, there are a number of advantages that digital PCR affords over other detection methods. I will discuss these advantages and review a number of novel digital PCR-dependent assays, which we have developed in our laboratory.

PCR MEASUREMENT AND ANALYSIS  

Reverse Transcription Digital PCR
Stephen Bustin, BA(Mod), Ph.D., FSB, Professor, Molecular Medicine, Postgraduate Medical Institute, Faculty of Medical Sciences, Anglia Ruskin University

Digital PCR Standards
Ross Haynes, Biological Science Technician, Biochemical Science Division, National Institute of Standards and Technology (NIST)

Defining Reference Standards for Digital PCR and Demonstrating Their Application in Circulating Tumor Assay Development
Jonathan Frampton, Ph.D., Global Product Manager,Horizon Diagnostics

Corporate Sponsor

Analysis and Visualization of Digital PCR Experiments - Applications of the dpcR Framework
Stefan Rödiger, Ph.D., Group Leader, InnoProfile, "Image-Based Assays", Brandenburg University of Technology

A Robust Framework for Digital PCR Data Analysis
Jo Vandesompele, Ph.D., CEO, Biogazelle; Professor, Ghent University

Day 2

dPCR FOR PATIENT MONITORING AND STRATIFICATION  

Digital PCR for Patient Monitoring and Stratification in Clinical Trials
Reinhold Pollner, Ph.D., Director, Clinical Trial Assay Development, Genoptix Medical Laboratory, a Novartis Company

Evaluation of EGFR Mutations in Plasma from NSCLC Patients: Utility in Managing Patients on TKI Therapy
Chris Karlovich, Ph.D., Principal Scientist, Molecular Diagnostics, Clovis Oncology

Serial Monitoring of EGFR Mutations in Plasma and Matched Tissue from EGFR Mutant Non-Small Cell Lung Cancer Patients on Erlotinib
Cloud P. Paweletz, Ph.D., Head, Translational Research Laboratory; Biomarker Lead, Belfer Institute for Applied Cancer Science, Dana Farber Cancer Institute

MINORITY TARGET DETECTION  

Digital PCR for Detecting Rare Genomic Alterations which Enhances Sensitivity in Cell-Free DNA
Rachel Tam, Senior Research Associate, Clinical Assay Development, Oncology Biomarker Development, Genentech, Inc.

Applications of Digital PCR in Oncology: Detecting Residual Disease in Plasma of Early Stage Breast Cancer Patients and Archival Tissue Studies Using Droplet Digital PCR
Rory L. Cochran, Ph.D. Candidate, Ben Ho Park Lab, Graduate Program in Cellular & Molecular Medicine, Johns Hopkins University School of Medicine

COPY NUMBER VARIATION  

Sponsored Presentation
Speaker to be Announced                                                                      


Corporate Sponsor

Development of Configurable Genotyping Assays for Single Color Digital PCR in Cancer
Hanlee P. Ji, M.D., Assistant Professor, Medicine, Division of Oncology, Stanford University School of Medicine

Evaluation of Genetic Stability of HSV Transgenes in a Constructed Vero Cell Line
Ali Azizi, Ph.D., Scientist, Adjunct Professor, Microbiology and Virology, Analytical Research and Development, sanofi pasteur

Sponsored Presentation
Speaker to be Announced                                                                      


Corporate Sponsor

Statistical Modeling Techniques for Setting Digital PCR-Based Quality Control Specifications
Douglas Sanders, Ph.D., Senior Scientist, Companion Diagnostics, Novartis

Day 3

Panel Discussion with Technology Vendors: Digital PCR Implementation Considerations
ModeratorRoss Haynes, Biological Science Technician, Biochemical Science Division, National Institute of Standards and Technology (NIST)

Panelists will include representatives from:

  • Bio-Rad
  • Horizon Diagnostics
  • Life Technologies
  • Sysmex Inostics GmbH

ABSOLUTE QUANTIFICATION  

The Application of Digital PCR to Infectious Disease Detection
Jim Huggett, B.Sc. (Hons), Ph.D., Science Leader, Nucleic Acid Metrology, Molecular & Cell Biology, LGC

dPCR and Beyond: Clinical Utility of Cell-Free Tumor DNA
Frank Holtrup, Ph.D., Head, R&D Service Laboratories,Sysmex Inostics GmbH


Corporate Sponsor

NGS-Assisted DNA-Based Digital PCR for the Detection and Quantification of Residual Disease in CML Patients with Undetectable BCR-ABL1 Transcripts
Mary Alikian, Imperial Molecular Pathology, Imperial Healthcare Trust, Hammersmith Hospital; Centre for Haematology, Faculty of Medicine, Imperial College London

Diagnostic Use of Digital PCR for Liquid Biopsy
Ekkehard Schütz, M.D., Ph.D., CTO, Senior Vice President, Research, Chronix Biomedical, Inc.

EMERGING DIGITAL BIOLOGY TECHNOLOGIES  

Featured Poster Presentations
Two posters outlining a new techonology or technique will be selected by the Scientific Advisory Board and the authors will be invited to give a 15-minute presentation on their work. Deadline to submit a poster is September 5, 2014. Full details.

On-Chip Integrated Digital PCR Technologies
Abraham "Abe" Lee, Ph.D., William J. Link Professor and Chair, Department of Biomedical Engineering, Director, Micro/Nano Fluidics Fundamentals Focus (MF3) Center, University of California, Irvine

PACS: PCR-Activated Cell Sorting
Adam R. Abate, Ph.D., Assistant Professor, Bioengineering and Therapeutic Sciences, California Institute for Quantitative Biosciences (QB3), University of California, San Francisco

The Amplinome Test: A Pan-Cancer Droplet Digital PCR (ddPCR) Based Assay Panel to Assess Gene Amplification Status in Solid Tumors
Austin P. So, Ph.D., Director, Research & Development, TOMA Biosciences

RECOMMENDED SHORT COURSES*

Digital PCR Experiment Design and Primer
Instructor
Jim Huggett, B.Sc. (Hons), Ph.D., Science Leader, Nucleic Acid Metrology, Molecular & Cell Biology, LGC
October 6, 9:00AM - 12:00PM

This course will introduce the concept of digital PCR (dPCR) and explain how it compares to other molecular methodologies, citing both advantages and disadvantages. Included in the discussion will be the application of dPCR to perform minority target detection, absolute quantification and measurement of copy number variation as well as the analysis of RNA using reverse transcriptase dPCR. The discussion will also include some of the specific challenges associated with performing this technique.

Dinner Short Course: Single-Cell Genomic Analysis
Instructor
Daniel T. Chiu, Ph.D., A. Bruce Montgomery Professor, Chemistry; Endowed Professor, Analytical Chemistry; Professor, Bioengineering, University of Washington, Seattle
October 7, 6:00PM -8:00PM

* Separate registration required

SPONSOR & EXHIBITOR OPPORTUNITIES

Opportunities include podium presentations available within the conference agenda, invitation only VIP dinners, Exhibit space, and more! For more details contact Jay Mulhern, Business Development Manager at 781-972-1359 or jmulhern@healthtech.com

View Final Agenda |Sponsor & Exhibit | Present a Poster | Register by July 18 & SAVE up to $400!

healthtech.com/Digital-PCR

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Tel: 781-972-5400 | Fax: 781-972-5425

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